2 die as Thai anti-government demonstrators lay siege to Parliament

BANGKOK, Thailand (CNN) - Two people died Tuesday when Thai police clashed with thousands of anti-government protesters who barricaded Parliament and prevented lawmakers from leaving.

One person died after a car bomb exploded near the protest area, officials said, and Ramathibhodi Hospital officials confirmed that a woman died from severe chest injuries suffered in the clash with police.

More than 420 people have been hurt, hospital officials said. A deputy prime minister who was charged with negotiating with the demonstrators resigned over the crackdown.